Choose components and a thermodynamic model appropriate to the mixture before assembling a large flowsheet. Verify one unit operation and its mass and energy balances, then add recycle loops or dynamic behavior gradually. Document property methods and operating assumptions so another engineer can distinguish simulation choices from measured process information.
This is best suited to chemical engineers and students modeling process flowsheets. Before committing a larger project, account for these trade-offs: property-method selection requires expertise; industrial decisions need validated assumptions.