Design a small schema with explicit keys and constraints, then test representative queries before adding indexes. Establish backups and restoration checks early, not only after the database grows. Use least-privilege accounts for applications and plan upgrades, monitoring, and capacity according to the workload rather than relying on default settings indefinitely.
This is best suited to applications needing a capable relational database. Before committing a larger project, account for these trade-offs: production databases need backup and monitoring; managed hosting is a separate cost.